|
KMID : 0603820130190030270
|
|
Journal of Experimental & Biomedical Science
2013 Volume.19 No. 3 p.270 ~ p.274
|
|
|
Isoliquiritigenin Inhibits Ovalbumin-induced Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression
|
|
Lim Se-Jin
Youn Hyung-Sun
|
|
|
Abstract
|
|
|
Egg allergy has been raised as the most prevalent food hypersensitivity in children. Ovalbumin (OVA), which is one
of the major egg allergens, is the major protein in egg white. Isoliquiritigenin (ILG) is an active component present in
licorice and has been used to treat many chronic diseases for many years. In this study, we present biochemical evidence that ILG inhibits OVA-induced nuclear factor-κB (NF-κB) activation. ILG also inhibits OVA-induced cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression. These data suggest that ILG has anti-allergy effects.
|
|
|
KEYWORD
|
|
|
Egg allergy, Isoliquiritigenin, Inducible nitric oxide synthase, Cyclooxygenase-2, Ovalbumin
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|